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Dihexa

N-hexanoic-Tyr-Ile-(6) aminohexanoic amide

Experimental cognitive compound that promotes new neural connections

NeuroactivePeptideRoute · oral / SubQ / topicalReviewed Apr 2026
01 — OVERVIEW
SYSTEMSHow Dihexa affects you

Grows new synapses in the hippocampus.

A small-molecule analog of angiotensin IV. Enhances HGF (hepatocyte growth factor) signaling in the brain, driving the formation of new synaptic connections.

  • Reported to be orders of magnitude more potent than BDNF at synaptogenesis in vitro.
  • Human data is essentially absent — mostly rodent models of Alzheimer's.
  • Attractive theoretical model but unknown safety profile long-term.

Dihexa was originally created to help with Alzheimer's disease. It helps your brain build new connections between brain cells — like adding new wires to a circuit board. In lab studies, it was millions of times more effective at building these connections than your brain's own growth chemicals. It's the most potent cognitive peptide known, but it's also very experimental.

02 — PHARMACOKINETICS

How long it stays, how it leaves.

Half-life
12 h
Default concentration
500 mg
Common vial sizes
500 mg

Fixed dosing — not weight-adjusted. The calculator handles reconstitution math for common vial sizes so you inject the right volume every time.

03 — DOSING PROTOCOL

Three tiers, three goals.

beginner2-4 weeks cycle
Dose
1020 mg
Frequency
Once daily (by mouth)
Cycle
2-4 weeks
intermediate4-8 weeks cycle
Dose
2040 mg
Frequency
Once daily
Cycle
4-8 weeks
advanced4-8 weeks cycle
Dose
4075 mg
Frequency
Once daily
Cycle
4-8 weeks

4 weeks on, 4 weeks off. Very experimental.

04 — SIDE EFFECTS

What people actually report.

  • Higher blood pressure (possible)
  • Headache
  • Very vivid dreams
05 — WARNINGS

Before you start.

  • Very experimental — limited human data
  • Extremely potent — always start with the lowest dose
  • Avoid if you have any history of cancer — it promotes cell growth
  • Talk to a doctor before considering this one
06 — STACKING & INTERACTIONS

Combinations worth knowing.

Brain Regeneration Stack

Dihexa builds new brain connections while Semax nourishes and protects them. Like building new roads and then paving them.

07 — CITATIONS & Q&A

Research behind the claims.

Wright JW, Kawas LH, Harding JW. · Progress in Neurobiology · 2015
Dihexa and related analogs activate the HGF/Met pathway to drive synaptogenesis, showing potent procognitive effects in rodent dementia models.
Sun X, Deng Y, Fu X, et al. · Brain Sciences · 2021
Dihexa reversed spatial memory deficits in an Alzheimer's mouse model by activating PI3K/AKT and promoting new synapse formation.

Ask anything, get cited answers.