Semaglutide
GLP-1 injection for weight loss and blood sugar control
GLP-1 agonism recalibrates appetite and insulin.
Activates the GLP-1 receptor on pancreatic β-cells and in the brainstem, boosting glucose-dependent insulin and telling the hypothalamus you're full.
- Slows gastric emptying — food sits longer, hunger fades sooner.
- Lowers glucagon when blood sugar is already normal.
- Also approved for reducing major cardiovascular events in T2D.
Semaglutide copies a gut hormone called GLP-1 that your body releases after eating. It signals your brain to feel full, slows how fast your stomach empties, and steadies your blood sugar. The effect is reduced appetite and smaller portions without feeling restricted. Sold as Ozempic for diabetes and Wegovy for weight loss.
How long it stays, how it leaves.
Fixed dosing — not weight-adjusted. The calculator handles reconstitution math for common vial sizes so you inject the right volume every time.
Three tiers, three goals.
This is just the starting dose — standard titration goes: 250 mcg (wks 1-4) → 500 mcg (wks 5-8) → 1 mg (wks 9-12) → 1.7 mg (wks 13-16) → 2.4 mg max
Only increase by 250–500 mcg every 4 weeks if nausea is tolerable
FDA-approved max for weight loss (Wegovy) is 2.4mg/week — most people never need to go this high
What people actually report.
- Nausea (very common — 44%)
- Vomiting
- Diarrhea or constipation
- Stomach pain
- Muscle loss if you don't exercise and eat enough protein
Before you start.
- FDA-approved as Ozempic (diabetes) and Wegovy (weight loss) — one of the most studied peptides in existence
- Never skip titration steps — jumping up in dose too fast is why people quit from nausea
- Standard titration: 250 mcg → 500 mcg → 1 mg → 1.7 mg → 2.4 mg, moving up only every 4 weeks
- See a doctor immediately for severe stomach pain (pancreatitis risk)
- Don't use if you have a personal or family history of thyroid cancer
- Lift weights and eat 0.7–1g of protein per lb of body weight to prevent muscle loss