PepTalk
Client-side only
Library

TB-500

Thymosin Beta-4

Recruits repair cells to injury sites and reduces scar tissue

Repair & RecoveryPeptideRoute · SubQ / IMReviewed Apr 2026
01 — OVERVIEW
SYSTEMSHow TB-500 affects you

Recruits repair cells to damaged tissue.

Avoid w/ cancer history

A synthetic fragment of thymosin-β4. Binds actin and organizes cytoskeleton assembly so stem cells and fibroblasts can migrate into wounds.

Onset
3–4 wk
Half-life
~60 h
  • Supports tendon, ligament, and muscle tissue remodeling.
  • Systemic (not site-local) effect — circulates to multiple injuries at once.
  • Often paired with BPC-157 in injury-recovery protocols.

TB-500 is a synthetic version of Thymosin Beta-4, a protein naturally present in most cells. It promotes cell migration to injured areas, helping repair cells reach damage faster. It's also been shown to reduce scar tissue formation, so healed muscle retains better flexibility.

02 — PHARMACOKINETICS

How long it stays, how it leaves.

Half-life
6 h
Default concentration
5000 mcg
Common vial sizes
5000 mcg

Fixed dosing — not weight-adjusted. The calculator handles reconstitution math for common vial sizes so you inject the right volume every time.

03 — DOSING PROTOCOL

Three tiers, three goals.

beginner4-6 weeks cycle
Dose
22.5 mg
Frequency
Twice weekly
Cycle
4-6 weeks
intermediate4-6 weeks cycle
Dose
2.55 mg
Frequency
Twice weekly
Cycle
4-6 weeks
advanced6-8 weeks cycle
Dose
510 mg
Frequency
Twice weekly
Cycle
6-8 weeks

Higher dose first 2 weeks, then lower

04 — SIDE EFFECTS

What people actually report.

  • Head rush right after injection
  • Feeling tired temporarily
  • Irritation at injection spot
05 — WARNINGS

Before you start.

  • Not FDA approved — research compound
  • Avoid if you have cancer — it promotes cell growth
  • Talk to a doctor before starting
06 — STACKING & INTERACTIONS

Combinations worth knowing.

Injury Recovery Stack

TB-500 recruits repair cells throughout the body; BPC-157 supports local healing at the injury site. The most commonly paired healing stack.

07 — CITATIONS & Q&A

Research behind the claims.

Kleinman HK, Sosne G. · Vitamins & Hormones · 2016
Thymosin β4 accelerated dermal healing by promoting angiogenesis, cell migration, and collagen deposition in multiple wound models.
Malinda KM, Sidhu GS, Mani H, et al. · Journal of Investigative Dermatology · 1999
Topical Tβ4 reduced wound closure time by 42% and doubled the rate of collagen deposition in a full-thickness wound model.

Ask anything, get cited answers.