Library
Kisspeptin
The Puberty Peptide
Kickstarts your body's own testosterone and fertility naturally
01 — OVERVIEW
SYSTEMSHow Kisspeptin affects you
Restarts the reproductive hormone axis.
The master regulator of the HPG axis. Binds hypothalamic KISS1R receptors, triggering GnRH release and kicking the whole cascade of LH, FSH, and sex hormones back into gear.
LH
↑
acute response
Onset
30–60 min
- Used clinically to trigger ovulation in fertility treatment.
- Restores pulsatile GnRH in hypogonadotropic hypogonadism.
- Promising research tool for amenorrhea and delayed puberty.
Kisspeptin is the first domino in your body's hormone chain. It tells your brain to start the whole process that ends with testosterone (in men) and reproductive hormones (in women). Unlike taking testosterone directly, kisspeptin works through your body's natural system — so your body stays in control. It's being researched for fertility and low testosterone.
02 — PHARMACOKINETICS
How long it stays, how it leaves.
Half-life
30 min
Default concentration
5000 mcg
Common vial sizes
5000 mcg
Fixed dosing — not weight-adjusted. The calculator handles reconstitution math for common vial sizes so you inject the right volume every time.
03 — DOSING PROTOCOL
Three tiers, three goals.
beginner4 weeks cycle
Dose
50–100 mcg
Frequency
Once daily
Cycle
4 weeks
intermediate4-8 weeks cycle
Dose
100–200 mcg
Frequency
Once daily
Cycle
4-8 weeks
advanced8-12 weeks cycle
Dose
200–400 mcg
Frequency
Once daily
Cycle
8-12 weeks
04 — SIDE EFFECTS
What people actually report.
- Redness at injection spot
- Mood changes
- Hot flashes
05 — WARNINGS
Before you start.
- Being actively researched for fertility treatments
- Doesn't shut down your natural hormone production
- May not work if your pituitary gland has issues
06 — STACKING & INTERACTIONS
No documented stacks yet.
07 — CITATIONS & Q&A
Research behind the claims.
First-in-human IVF study: kisspeptin-54 reliably triggered oocyte maturation with lower ovarian hyperstimulation risk than standard hCG triggers.
02Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of Ovarian Hyperstimulation SyndromePMID 26192876
Kisspeptin-54 safely triggered oocyte maturation in high-risk IVF patients, preventing the dangerous hyperstimulation syndrome associated with hCG.
Review establishing kisspeptin as the master regulator of GnRH pulsatility and a validated clinical target for infertility and hypogonadism.