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Selank

The Anti-Anxiety Peptide

Melts anxiety without making you sleepy — calm and focused

NeuroactivePeptideRoute · nasalReviewed Apr 2026
01 — OVERVIEW
SYSTEMSHow Selank affects you

Calms anxiety without sedation.

A synthetic analog of tuftsin. Acts on GABAergic tone and raises BDNF, producing benzodiazepine-like anxiolysis without the sedation, memory impairment, or dependence.

Onset
15–20 min
intranasal
Duration
3–4 h
  • No rebound anxiety, tolerance, or withdrawal reported.
  • Studied in Russia for generalized anxiety disorder.
  • Clinical effect within 15–20 minutes of intranasal dosing.

Selank is like a chill pill that doesn't make you drowsy. It balances the feel-good chemicals in your brain (serotonin and dopamine) so you feel calm but still sharp. Unlike anti-anxiety meds that can make you foggy or sleepy, Selank keeps you clear-headed. It also helps your immune system, which is a nice bonus. Taken as a nasal spray.

02 — PHARMACOKINETICS

How long it stays, how it leaves.

Half-life
18 min
Default concentration
3000 mcg
Common vial sizes
3000 mcg

Fixed dosing — not weight-adjusted. The calculator handles reconstitution math for common vial sizes so you inject the right volume every time.

03 — DOSING PROTOCOL

Three tiers, three goals.

beginner2-4 weeks cycle
Dose
200400 mcg
Frequency
Once daily (nasal spray)
Cycle
2-4 weeks
intermediate4-8 weeks cycle
Dose
400750 mcg
Frequency
1-2 times daily
Cycle
4-8 weeks
advanced4-8 weeks cycle
Dose
7501000 mcg
Frequency
2 times daily
Cycle
4-8 weeks
04 — SIDE EFFECTS

What people actually report.

  • Nose irritation
  • Tiredness at high doses
  • Allergic reaction (rare)
05 — WARNINGS

Before you start.

  • Approved medication in Russia for anxiety
  • Not addictive — no withdrawal when you stop
  • Doesn't slow you down or mess with reaction time
06 — STACKING & INTERACTIONS

Combinations worth knowing.

Calm Focus Stack

Selank handles the anxiety while Semax boosts your brainpower. You get sharp focus without the stress. Great for high-pressure work.

07 — CITATIONS & Q&A

Research behind the claims.

Medvedev VE, Tereshchenko ON, Israelian AIu, et al. · Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova · 2014
Selank produced comparable anxiolytic effects to phenazepam (benzodiazepine) without sedation, memory impairment, or dependence.
Konstantinopolsky MA, Chernyakova IV, Kolik LG. · Bulletin of Experimental Biology and Medicine · 2022
Selank attenuated anxiety and withdrawal signs in opioid-dependent rats, supporting its GABA-modulatory mechanism.

Ask anything, get cited answers.