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SS-31

Mito Peptide

Repairs your cells' power plants so they run clean and efficient

MitochondrialPeptideRoute · SubQReviewed Apr 2026
01 — OVERVIEW
SYSTEMSHow SS-31 affects you

Protects and energizes mitochondria.

Elamipretide (SS-31) binds cardiolipin in the inner mitochondrial membrane, stabilizing electron-transport complexes and cutting reactive oxygen species production.

  • Studied for heart failure, primary mitochondrial disease, and age-related muscle weakness.
  • Improves ATP production efficiency per oxygen consumed.
  • Protective against ischemia-reperfusion injury in preclinical models.

Every cell has tiny power plants called mitochondria. Over time, these power plants get leaky and damaged — like an old car engine. SS-31 goes inside and patches the leaks, so your mitochondria can produce energy cleanly again without as much 'exhaust' (damaging waste). It's like getting a tune-up for every cell in your body. Currently being tested for heart failure.

02 — PHARMACOKINETICS

How long it stays, how it leaves.

Half-life
4 h
Default concentration
10000 mcg
Common vial sizes
10000 mcg

Fixed dosing — not weight-adjusted. The calculator handles reconstitution math for common vial sizes so you inject the right volume every time.

03 — DOSING PROTOCOL

Three tiers, three goals.

beginner4 weeks cycle
Dose
1020 mg
Frequency
Once daily
Cycle
4 weeks
intermediate4-8 weeks cycle
Dose
2040 mg
Frequency
Once daily
Cycle
4-8 weeks
advanced8-12 weeks cycle
Dose
4040 mg
Frequency
Once daily
Cycle
8-12 weeks

40mg/day was the clinical trial dose

04 — SIDE EFFECTS

What people actually report.

  • Pain at injection spot
  • Headache
  • Nausea (uncommon)
05 — WARNINGS

Before you start.

  • Being tested in real clinical trials for heart failure
  • One of the most-studied mitochondrial peptides
  • Expensive — hard to make and limited supply
06 — STACKING & INTERACTIONS

Combinations worth knowing.

Cellular Energy Stack

SS-31 fixes the hardware (power plant walls) while MOTS-c activates the software (exercise signals). Complete cellular energy upgrade.

07 — CITATIONS & Q&A

Research behind the claims.

Chavez JD, Tang X, Campbell MD, et al. · Proceedings of the National Academy of Sciences · 2020
SS-31 binds cardiolipin in the inner mitochondrial membrane, stabilizing electron transport chain complexes and reducing ROS production.
Butler J, Khan MS, Anker SD, et al. · Journal of Cardiac Failure · 2020
Phase 2 trial in HFrEF patients: elamipretide (SS-31) improved left ventricular end-systolic volume index and quality of life vs. placebo.

Ask anything, get cited answers.